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Hais txog Silibinin(Silybin)

Source:Wikipedia | Updated: Mar 25, 2016

Silibinin(INN), los yogsilybin(ob leeg los ntawmSilybum, tusgenericnpe ntawm covtsob nrojlos ntawm qhov uas nws yog muab rho tawm), yog tus loj lub tog neeg twg uassilymarin, ib caag extract ntawm tusmis thistlenoob uas ntiavflavonolignanshom silibinin,isosilibinin,silicristin,silidianinthiab lwm tus. Silibinin xwb yog ntawm ob tugdiastereomers, silybin A thiab silybin B, rau piv li ntawm equimolar.

Pharmacology

Txom nyem dej solubility thiabbioavailabilityntawm silymarin mus rau txoj kev enhanced formulations coj.Silipide(trade nameSiliphos), ib complex ntawm silymarin thiabphosphatidylcholine(lecithin), yog li 10 zaug ntxiv bioavailable li silymarin.[3]Ib yavtxoj kev tshawv nomuaj xaus lus Siliphos muaj 4.6 quav ntau dua bioavailability.[4]Nws kuj tseem qhia tias silymarin menyuamuas txoj nrog β -cyclodextrinyog soluble ntau ntau dua silymarin xwb.[5]Muaj muaj los kuj raug npajglycosidesntawm silybin, uas pom zoo solubility dej thiab tseem muaj zog hepatoprotective nyhuv.[6]

Silymarin, ua lwm yamflavonoids, yeej pom tias inhibitP-glycoprotein-mediated cellular efflux.[7]Cov tes taws los piav txog txoj kev P-glycoprotein tej zaum yuav raug nyob hauv no ib haum thiab cov tshuaj uas P-glycoprotein substrates bioavailability. Nws tau raug tus mob no cheeb qhov uas cov silymarin ntawdcytochrome P450enzymes thiab kev sis raug zoo nrog cov tshuaj uas feem ntau cleared los P450s tsis tau yuav tsis tau mus.[8]

Toxicity

Atheem kuv mus sib hais tejrau cov tib neeg uas muaj mob cancer prostate txug kev kawm cov kev los ntawm koob siab silibinin nyob 13 grams ib hnub mus zoo zam rau cov neeg uas txawm prostate cancer rau daim siab asymptomatic toxicity (hyperbilirubinemiathiab nce ntawmalanine aminotransferase) yog phiv tej seen feem ntau.[9]

Silymarin tseem devoid of embryotoxic tej tsiaj tej qauv.[10][11]

Kev siv

Silibinin muaj li tshuaj (Legalon® SIL (Madaus) (D, CH, A) thiab Silimarit® (Bionorica), ib yam khoom Silymarin) nyob rau hauv tej lub teb chaws EU thiab siv kho zoo daim siab puas (xws li IV kho thaum poinsining tuag cap); raws li adjunctive kho mob hepatits thiab mob npuas paug. XyuasSilybum_marianum #Medicinal_use

Tej kev siv

Silibinin nyob rau hauv kev tshawb nrhiav pom tau hais tias nws yuav muaj lub luag hauj lwm hauv kev kho mob cancer (yam li cov neeg vim nws cov inhibition uas yogSTAT3nrov tas mus li).[12]

Silibinin muaj ib tug xov tooj ntawm cov mechanisms ntau qhov uas yuav zoo rau tej tawv nqaij. Cov no muaj xws li chemoprotective los ntawm tej co toxins, sau tej teebmeem, tiv thaiv tau UV vim raug yuam photocarcinogenesis, tiv thaiv tshav kub daim tawv, kev tiv thaiv los ntawm hob UVB epidermal hyperplasia, thiab DNA kho tau UV vim raug yuam DNA puas tsuaj.[13]

Biotechnology

Silymarin yuav tau ua nyob rau hauvkaubthiab hlwb tawm ntawmSilybum marianumthiab pawgpyrazinecarboxamidesyuav siv li abioticelicitorsntawm cov flavolignan ntau lawm.[14]

Kev nug
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